Pawan Jolly, PhD

Senior Scientist, Team Lead (2018-present)

• ​Establishing point-of-care devices for medical diagnostic applications. 

• Developing lateral flow and paper-based assays for small molecule detection 

• Designing CRISPR electronics 

• Prototyping and commercialisation

Scientist, Co-Team Lead (2017-2018)

• Established point-of-care device for the detection of the early onset of allergies.

• Developed assays for the detection of small molecules in complex samples

• Worked on the development of wearable glucose sensor (non-invasive enzymatic sensor)

• Developed of PCB-based biosensor for nucleic acid detection

• Developed affimer-based (peptide probes) biosensor for the detection of protein biomarkers

• Optimized synthetic oligonucleotide-based field-effect transistors (Bio-FET) for the development of an In-Vitro Diagnostic (IVD) medical device for pathogenic DNA detection (Clostridium difficile)

       "Towards a rapid, hand-held, biosensor-based detector for Clostridium difficile"

• Awarded Marie Curie scholarship selected from across the world for academic prowess and demonstrated leadership, achieving the opportunity to design and generate various interdisciplinary strategies for the development of DNA-based biosensors, cultivating cutting-edge and industry-specific research tactics and relevant methodologies

• Developed DNA-aptamer-based sensors for the detection of multiple biomarkers for prostate cancer and breast cancer

• Developed PNA-based sensors for the detection of DNA/miRNA

Visiting Researcher (2015)

• Led the design, development, and project coordination for novel peptide-based probes (Affimer® technology,) for detection of the prostate cancer biomarker, establishing high-level skills in biotechnology and biomedical-based health interventions

Visiting Researcher (2014 and 2015)

• Developed DNA-based microfluidic assays using optical detection technique (chemiluminescence) for detection of biomarkers of prostate cancer (Quantification and Glycoprofiling of protein biomarker). Highlight: development of ELISA-based assays by employing DNA aptamers in the place of antibodies

• Established and implemented a new strategy to detect a prostate cancer biomarker with 10 fold increase in sensor efficiency

Visiting Researcher (2013)

• Enhanced overall biosensor efficiency, through the establishment of a novel molecule, to enhance surface chemistry

• Worked on a new immobilization technique for DNA aptamers with improved surface chemistry for antifouling properties 

Biosensor Researcher (2011-2012)

• Simplified overall process flow, through sensor optimization for the purpose of multiplexing in an opto-magnetic biosensor for the mass production of disposable sensor cartridges (IVD)

• Worked as a Biosensor Researcher in the field of optomagnetic biosensors. (creation, design and testing) in the field of molecular diagnostics. It involves varied skills of biotechnology and biomedical engineering.
  
  "Optimization of structured sensor surfaces for multiplexing in an optomagnetic bio-sensor for point of care diagnostics"

Student Research Assistant (2010-2011)

• Worked on the development of an electrochemical sensor (amperometric) in combination with field effect devices for dissolved hydrogen gas detection and pH measurement for anaerobic fermenters